What is the appropriate pharmacologic treatment to prevent permanent deafness in sudden sensorineural hearing loss?

Corticosteroids are the appropriate pharmacologic treatment to prevent permanent deafness in sudden sensorineural hearing loss. The use of corticosteroids is based on their ability to reduce inflammation and edema in the cochlea, which can help minimize further damage to hair cells and auditory pathways. Early intervention with corticosteroids, ideally within a few days of symptom onset, has been shown to improve the chances of hearing recovery in patients experiencing this type of hearing loss.

While diuretics may serve a purpose in cases of fluid overload or specific conditions like Meniere's disease, they do not address the underlying inflammatory processes seen in sudden sensorineural hearing loss. Antibiotics are indicated for infectious causes of hearing loss but are not effective when the cause is idiopathic or related to other non-infectious factors. NSAIDs provide analgesic and anti-inflammatory effects, but they are not effective for the specific inflammatory response associated with sudden sensorineural hearing loss, making corticosteroids the key treatment option in this scenario.