What is a common initial pharmacological treatment for patients experiencing migraines?

The choice of rizatriptan as a common initial pharmacological treatment for migraines is supported by its classification as a triptan. Triptans are specifically designed to treat migraine headaches and are considered first-line therapy due to their effectiveness in alleviating the symptoms of an active migraine attack. Rizatriptan works by agonizing serotonin receptors in the brain, which helps to narrow dilated blood vessels and reduce inflammation, directly addressing the pathophysiology of migraines.

While ibuprofen and acetaminophen are both commonly used for mild-to-moderate headaches and can be effective in some cases, they do not target the underlying mechanisms of migraines in the same way triptans do. Metoclopramide may be used as an adjunct to treat nausea associated with migraines or to enhance the efficacy of analgesics but is not typically the first line for the migraine itself. Hence, the selection of rizatriptan highlights its specific role in treating migraines distinctly.